Complete Mitochondrial DNA Sequences

The Cambridge Reference Sequence:

Version Genbank # Fasta format Article links
RevisedCambridge Reference Sequence ("rCRS")
Two identical versions of the rCRS are available on Genbank. Either may be used and/or cited as the rCRS.

AC_000021.2 is in GenBank's RefSeq database. It is the most commonly used rCRS and is the standard comparison sequence for human mtDNA research.

J01415.2 is the fully corrected update of the original Cambridge sequence and is identical to AC_000021.2.

You may use the links to the right or you may search Genbank for the rCRS.

View Mitomap's fully annotated rCRS sequencehere.

AC_000021.2
gi:115315570

-OR-
J01415.2
gi:113200490

 

rCRS-fasta

 

Andrews et al 1999(PubMed

  • Read the paper (PDF)

  • <ahref="CambridgeReanalysis.htm">Summary table of corrections.
Original Cambridge Reference Sequence ("CRS") J01415(".0")
gi:337188
CRS1981-fasta

Anderson et al 1981 (PubMed? )

Version history of the J01415 CRS:

J01415 gi:337188(1981-1995) preserves the original Cambridge sequence ofAnderson et al 1981. It contains the all of the rare polymorphisms as originally pubished but not the subsequent 11 error corrections of Andrews et al 1999.

J01415.1 gi:1944628 (1997-2001) should not be used as it is missing one of the original rare polymorphisms ofAnderson et al 1981 and has some but not all of the rCRS corrections of Andrews et al 1999. It does not have750A (1 of the 7 rare polymorphisms),

3107del, 4985A,

11335C or 14766C (4 of the subsequent error corrections).

J01415.2 gi:113200490 (1999-2008) is the final revision of the original Cambridge sequence. It is fully corrected and is the same as REFSEQ AC_000021.2, gi:115315570. J01415.2 or AC_000021.2 may be used interchangeably as the rCRS reference standard.

Other reference hmtDNAs in GenBank:
Swedish Sequence X93334 This sequence has over 30 variant nucleotides from the rCRS.
African (Yoruba) Sequence NC_001807.4 This sequence has over 40 variant nucleotides from the rCRS.
Japanese Sequence AB055387 This sequence has over 50 variant nucleotides from the rCRS.
African (Uganda) Sequence D38112 This sequence has over 90 variant nucleotides from the rCRS.

To find >5200 complete human mtDNAs in GenBank: execute search.

To find >8800 complete eukaryote mtDNA genomes in GenBank: execute search.

Partial sequences are also available for Homo sapiens neanderthalensis mtDNA.



Representative Complete Mitochondrial Genomes of different organisms at NCBI:

Topic revision: r8 - 29 May 2009 - 10:39:55 - MartyBrandon
 
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